Effects of excess protein intake on nitrogen utilization in young men

The efficiency of nitrogen (N) utilization was studied in 12 young male subjects. Protein intake levels were adjusted from moderate (1.08 and 1.18 g protein/kg/day) to high (1.74 and 2.00 g protein/kg/day). All of the food was supplied in the form of a normal mixed Chinese diet. Six subjects were admitted to a metabolic unit at a time for 56 days, in two consecutive periods. The results indicate that a higher protein intake causes more N excretion in urine and feces. Biologic value (BV) and net protein utilization (NPU) were markedly decreased during the high protein intake (HPI) period. However, a significant increase in the N balance was found in the presence of excessive protein intake. Digestibility of protein seemed to increase during the HPI period, with the apparent digestibility of the dietary protein being about 83% to 90%. We conclude from this study that excessive N intake reduces the efficiency of N utilization, but still results in a positive N balance in adult human subjects.