Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neisserial surface variation: how and why?

J Swanson1, R J Belland, S A Hill

  • 1Rocky Mountain Laboratories, National Institutes of Health, Hamilton, Montana.

Current Opinion in Genetics & Development
|October 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Experimental verification of principal losses in a regulatory particulate matter emissions sampling system for aircraft turbine engines.

Aerosol science and technology : the journal of the American Association for Aerosol Research·2022
Same author

Relationship between distance to overhead power lines and calculated fields in two studies.

Journal of radiological protection : official journal of the Society for Radiological Protection·2020
Same author

Potential for biocolloid transport of cesium at high ionic strength.

Chemosphere·2019
Same author

Changes over time in the reported risk for childhood leukaemia and magnetic fields.

Journal of radiological protection : official journal of the Society for Radiological Protection·2019
Same author

Acinetobacter - the trojan horse of infection control?

The Journal of hospital infection·2018
Same author

Reanalysis of risks of childhood leukaemia with distance from overhead power lines in the UK.

Journal of radiological protection : official journal of the Society for Radiological Protection·2018
Same journal

Temporal trajectories underlying adult neuronal diversity.

Current opinion in genetics & development·2026
Same journal

Transcription regulation of cell fate plasticity - from embryonic development to tissue regeneration.

Current opinion in genetics & development·2026
Same journal

Shared molecular and cellular programs during regeneration of glandular epithelia.

Current opinion in genetics & development·2026
Same journal

Lineage tracing in human cortical development.

Current opinion in genetics & development·2026
Same journal

Cis-regulatory strategies in developmental patterning.

Current opinion in genetics & development·2026
Same journal

GABAergic neuron fate specification and lineage allocation: from development to disorder.

Current opinion in genetics & development·2026
See all related articles

Neisseria gonorrhoeae shows significant changes in surface molecules like pili and Opa proteins. This variation in the mucosal pathogen differs from blood-borne bacteria, though some molecular mechanisms may overlap.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Pathogenesis

Background:

  • Neisseria gonorrhoeae is a mucosal pathogen known for its ability to alter surface components.
  • Key surface structures include pili, Opa proteins, and lipooligosaccharide, which are crucial for host interaction and immune evasion.
  • This variability is particularly pronounced compared to other pathogens.

Purpose of the Study:

  • To highlight the extensive variation of surface components in Neisseria gonorrhoeae.
  • To contrast this variation with surface component changes in other pathogens like trypanosomes and borreliae.
  • To explore potential shared molecular mechanisms underlying these variations.

Main Methods:

  • Comparative analysis of surface component variability in Neisseria gonorrhoeae.

Related Experiment Videos

  • Literature review and comparison with surface variation mechanisms in blood-borne pathogens.
  • Identification of common molecular events involved in surface component modulation.

    • Main Results:

    • Neisseria gonorrhoeae displays remarkable and rapid variation in pili, Opa proteins, and lipooligosaccharide.
    • This extensive surface antigen switching is distinct from the more limited changes observed in single surface components of trypanosomes and borreliae.
    • Despite differences in the extent and targets of variation, certain molecular events appear to be conserved across these diverse pathogens.

    Conclusions:

    • The pronounced surface variability of Neisseria gonorrhoeae is a key feature of its pathogenesis.
    • While distinct from other pathogens, the underlying molecular machinery for surface variation may share common elements.
    • Further research into these shared mechanisms could offer insights into pathogen adaptation and immune evasion strategies.