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Related Experiment Videos

Hearing thresholds in CAPD patients.

L P Morton1, L Reynolds, R Zent

  • 1Department of Logopaedics, Groote Schuur Hospital, South Africa.

Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis
|January 1, 1992
PubMed
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Continuous ambulatory peritoneal dialysis (CAPD) patients show a high incidence of hearing loss, particularly at ultra-high frequencies (UHF). This hearing impairment is not linked to the duration of kidney failure or ototoxic drug exposure.

Area of Science:

  • Nephrology
  • Audiology
  • Ototoxicology

Background:

  • Chronic renal failure (CRF) affects multiple organ systems.
  • Hearing loss is a potential complication in patients with CRF.
  • Continuous ambulatory peritoneal dialysis (CAPD) is a common treatment for CRF.

Purpose of the Study:

  • To investigate the prevalence of hearing loss in stable CAPD patients.
  • To assess hearing thresholds at both conventional and ultra-high frequencies (UHF).
  • To determine the relationship between hearing loss and factors like CRF duration, ototoxic drug use, and vancomycin therapy.

Main Methods:

  • Audiometric thresholds were measured in 42 stable CAPD patients using conventional (0.25-8 kHz) and ultra-high frequencies (UHF, 10-20 kHz).
  • Patient data on CRF duration and ototoxic drug history were collected.

Related Experiment Videos

  • A subset of 16 patients was monitored for hearing changes during vancomycin treatment for peritonitis.

    • Main Results:

    • 50% of CAPD patients exhibited UHF hearing loss, and 25% had conventional hearing loss compared to age-matched controls.
    • Hearing loss was not correlated with the duration of CRF or the number of ototoxic drug treatments.
    • No significant changes in hearing thresholds were observed during vancomycin therapy.

    Conclusions:

    • There is a high incidence of hearing loss in CAPD patients.
    • The observed hearing loss in CAPD patients appears unrelated to ototoxic drug exposure.
    • Further research is warranted to explore the underlying causes of hearing impairment in this population.