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Related Experiment Videos

[Undescended testicle treated with FSH and HCG].

A Aznar Aznar1, A López García-Viedma, C Gómez Vilanova

  • 1Servicio de Cirugía Infantil, Hospital Militar Gómez Ulla, Madrid.

Anales Espanoles De Pediatria
|December 1, 1992
PubMed
Summary

Hormone therapy using follicle-stimulating hormone (FSH) and human chorionic gonadotropin (HCG) effectively increased testicular size and testosterone levels in cases of undescended testis. This treatment resulted in a significant descent rate of 68% for previously undescended testes.

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Area of Science:

  • Pediatric Endocrinology
  • Reproductive Medicine
  • Urology

Background:

  • Undescended testis, or cryptorchidism, is a common congenital condition in pediatric patients.
  • Delayed treatment or untreated cryptorchidism can lead to infertility and an increased risk of testicular cancer.
  • Hormonal therapy is a recognized, albeit debated, treatment option for undescended testis.

Purpose of the Study:

  • To evaluate the efficacy of a 21-day medical treatment regimen using follicle-stimulating hormone (FSH) and human chorionic gonadotropin (HCG) in managing undescended testis.
  • To assess the impact of this hormonal therapy on testicular volume and serum testosterone levels.
  • To determine the rate of testicular descent following the treatment protocol.

Main Methods:

  • A cohort of 47 patients (76 testes) diagnosed with undescended testis received a 21-day course of FSH and HCG treatment.

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  • Testicular volume was measured using ecography before, immediately after, and at 3 and 6 months post-treatment.
  • Serum levels of total and free testosterone were analyzed to assess hormonal changes.

    • Main Results:

    • Average testicular volume significantly increased from 0.828 cc to 1.57 cc within 48 hours of treatment completion.
    • Testicular volume remained elevated at 1.025 cc and 1.24 cc at 3 and 6 months, respectively.
    • Significant increases in total and free testosterone levels were observed, with a slight increase in FSH.
    • A notable 68% of previously undescended testes achieved spontaneous descent after the treatment.

    Conclusions:

    • A 21-day medical treatment with FSH and HCG is effective in increasing testicular volume and serum testosterone levels in patients with undescended testis.
    • The hormonal therapy demonstrates a significant success rate in achieving testicular descent, offering a viable non-surgical option.
    • Further research may explore long-term outcomes and optimal treatment durations for cryptorchidism management.