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Related Experiment Videos

Tuberculosis after corticosteroid therapy.

S A Sahn, S Lakshminarayan

    British Journal of Diseases of the Chest
    |July 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Corticosteroid use can trigger tuberculosis reactivation, especially in immunocompromised patients. Early antituberculosis treatment is effective, but careful consideration of preventive therapy is needed.

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    Area of Science:

    • Immunology
    • Infectious Diseases
    • Pulmonology

    Background:

    • Corticosteroids are widely used for their anti-inflammatory and immunosuppressive properties.
    • Tuberculosis (TB) reactivation is a known risk associated with immunosuppression.
    • Understanding the interplay between corticosteroid therapy and TB reactivation is crucial for patient management.

    Observation:

    • Fourteen cases of tuberculosis reactivation following corticosteroid administration were documented.
    • Most patients had underlying conditions impairing host defenses, and some received additional immunosuppressants.
    • Common symptoms included productive cough and malaise, with bronchoscopy needed for diagnosis in some instances.

    Findings:

    • Antituberculosis therapy demonstrated a good response in all reported cases.

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  • Five episodes involved dissemination of pulmonary tuberculosis, particularly in patients on high-dose corticosteroids and other immunosuppressants.
  • Sputum conversion time was not prolonged despite corticosteroid use.

    • Implications:

    • The findings necessitate a reevaluation of isoniazid (INH) chemoprophylaxis in patients with healed tuberculosis receiving corticosteroids.
    • Potential liver damage from INH requires balancing the risks and benefits of preventive therapy.
    • This highlights the importance of monitoring for TB reactivation in patients on corticosteroids, especially those with compromised immunity.