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Ocular side effects of selected systemic drugs.
Optometry Clinics : the Official Publication of the Prentice Society
|January 1, 1992
Summary
Systemic medications can cause various adverse ocular effects, including pigmentary changes, dry eye, vision changes, and retinal toxicity. Ophthalmic examination is crucial for patients taking systemic drugs to detect these drug-induced eye conditions.
Area of Science:
- Ophthalmology
- Pharmacology
- Toxicology
Background:
- Many systemic drugs have potential adverse effects impacting ocular health.
- Ocular side effects range from mild to severe, affecting various parts of the eye.
Purpose of the Study:
- To review and categorize the adverse ocular effects associated with systemic drug use.
- To inform healthcare professionals about potential drug-induced eye conditions.
Main Methods:
- Literature review of systemic drugs and their documented ocular side effects.
- Categorization of adverse effects by ocular structure or symptom.
Main Results:
- Systemic drugs can cause pigmentary changes (lids, conjunctiva), conjunctivitis, dry eye, keratopathy, lenticular deposits, refractive errors, mydriasis, extraocular muscle dysfunction, elevated intraocular pressure, and retinal toxicity.
- Specific drug classes linked to these effects include amiodarone, chlorpromazine, corticosteroids, antimalarials, and antituberculosis agents.
Conclusions:
- Adverse ocular effects are a significant consideration in patients using systemic medications.
- Awareness and monitoring are essential for early detection and management of drug-induced ocular conditions.