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Tolerance during dosing with H2-receptor antagonists. An overview
1Dept. of Medicine, Inselspital, University of Berne, Switzerland.
Scandinavian Journal of Gastroenterology. Supplement
|January 1, 1992
Summary
Tolerance to H2-receptor antagonists develops with repeated oral and intravenous dosing, potentially impacting conditions requiring strict acid control. However, this effect is minimal in duodenal ulcer disease patients.
Area of Science:
- Pharmacology
- Gastroenterology
Background:
- Tolerance to H2-receptor antagonists (H2RAs) is established with oral dosing in healthy volunteers.
- Anecdotal evidence suggests tolerance may also occur with intravenous H2RA administration.
Purpose of the Study:
- To investigate the clinical relevance of H2RA tolerance in conditions requiring precise acid suppression.
- To assess the development of tolerance in patients with duodenal ulcer disease.
Main Methods:
- Review of existing literature on H2RA tolerance.
- Analysis of sparse investigations concerning duodenal ulcer disease patients.
Main Results:
- Tolerance to H2RAs may be clinically significant in diseases needing tight acid control.
- Duodenal ulcer disease patients exhibit minimal tolerance development to H2RAs.
Conclusions:
- H2RA tolerance has minor clinical significance in duodenal ulcer healing failures.
- The underlying mechanisms of H2RA tolerance remain to be elucidated.