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In vitro Functional Characterization of Mouse Colorectal Afferent Endings
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Visceral and somatic sensory function in functional dyspepsia.

X Li1, Y Cao, R K M Wong

  • 1Dept of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Neurogastroenterology and Motility
|November 23, 2012
PubMed
Summary

Patients with functional dyspepsia (FD) exhibit visceral hypersensitivity involving Transient Receptor Potential Vanilloid-1 (TRPV(1)) pathways. Some also show somatic hypersensitivity, indicating central sensitization.

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Area of Science:

  • Gastroenterology
  • Neuroscience
  • Pain Research

Background:

  • Visceral hypersensitivity is a proposed mechanism in functional dyspepsia (FD).
  • The role of central sensitization, including somatic sensitization, in FD-related visceral hypersensitivity is unclear.
  • Transient Receptor Potential Vanilloid-1 (TRPV(1)) pathways are implicated in gastric mechanosensory processing.

Purpose of the Study:

  • To investigate visceral and somatic sensory function in functional dyspepsia (FD) patients.
  • To determine if visceral hypersensitivity in FD is associated with central sensitization.
  • To evaluate the involvement of TRPV(1) pathways in FD.

Main Methods:

  • A double-blind, randomized study involving 34 FD patients and 42 healthy controls.
  • Quantitative sensory testing was employed to assess visceral and somatic sensitivity.
  • Visceral sensitivity was measured using oral capsaicin titration; somatic sensitivity was assessed via thermal and electrical stimulation.

Main Results:

  • FD patients required a significantly lower median capsaicin dose (0.5mg) to elicit moderate pain compared to controls (1mg).
  • Mean pain intensity at these doses was significantly higher in FD patients (56.9) than in controls (45.1).
  • While overall somatic sensitivity was similar, a subgroup of FD patients demonstrated hypersensitivity in both hand and foot stimulation tests.

Conclusions:

  • The majority of FD patients exhibit visceral chemo-hypersensitivity, implicating TRPV(1) pathways.
  • A significant subgroup of FD patients also presents with somatic hypersensitivity, supporting the hypothesis of central sensitization.
  • These findings suggest that central sensitization mechanisms contribute to sensory abnormalities in functional dyspepsia.