Plasma insulin response to glibornuride in thyrotoxicosis

The glycemic and insulinemic response to i.v. glibornuride injection has been studied in a group of 8 euthyroid subjects and in a group of 9 thyrotoxic patients before and after reserpine treatment. In thyrotoxic patients sulfonylurea did not lower blood glucose more than in normal subjects. The plasma insulin response, however, was definitely higher than that of the controls in the first few minutes; after the 20th minute, however, levels of insulinemia were not appreciably different in the two groups. Insulin delivery rate was greater in hyperthyroid patients than in the controls. Administration of reserpine for a few days, did not modify either insulin response or blood glucose fall in thyrotoxic patients.