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[Schizophrenia and immunity]
A Galinowski1, P Levy-Soussan, H Lôo
1Service hospitalo-universitaire de santé mentale et de thérapeutique, Hôpital Sainte Anne, Paris.
Annales Medico-Psychologiques
|February 1, 1992
Abstract:
In schizophrenia, various modifications of the immune system have been reported. A decrease of interleukin-2 production by T lymphocytes and an increase of IL-2 receptors were observed by several authors. Not only cellular but humoral immunity seems to be modified: apart from the viral hypothesis, an auto-immune hypothesis holds that auto-antibodies may play a role in the biology of schizophrenia. Natural auto-antibodies, preexisting any antigenic stimulation, may also be involved, particularly in the response to neuroleptic drugs.