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Sodium, calcium and exocytosis: confessions of calcified scientists
J Nordmann1, M Lindau, E L Stuenkel
1LNMIC Centre de Neurochimie, Strasbourg, France.
Abstract:
Stimulated exocytotic secretion from nerve endings is initiated by an increase in intracellular free calcium concentration. We summarize here our latest findings regarding the temporal relationship between depolarization, elevation of [Ca2+]i and exocytosis in single vertebrate neuroendocrine nerve endings. In addition, we present surprising findings for a regulatory role of intracellular Na+ on exocytosis.
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