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Related Experiment Videos

CD4+ lymphocyte involvement in ocular Behçet's disease.

D G Charteris1, K Barton, A C McCartney

  • 1Department of Clinical Science, Institute of Ophthalmology, London.

Autoimmunity
|January 1, 1992
PubMed
Summary

Behçet

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Area of Science:

  • Ophthalmology
  • Immunology
  • Pathology

Background:

  • Behçet's disease causes severe ocular inflammation and vision loss.
  • Pathogenic mechanisms and ocular cellular infiltrates remain unclear.

Purpose of the Study:

  • To investigate cellular infiltrates in Behçet's disease ocular inflammation.
  • To elucidate mechanisms perpetuating ocular inflammation.

Main Methods:

  • Immunohistochemical staining of five enucleated Behçet's disease eyes.
  • Comparison with control eyes with chronic intraocular inflammation.

Main Results:

  • Mononuclear cell infiltrates, predominantly CD4+ T lymphocytes, were found in choroid and periretinal scars.
  • Macrophages were present; B lymphocytes and NK cells were infrequent.
  • No complement or immunoglobulin deposits were detected; infiltrating cells were HLA DR positive.

Conclusions:

  • Cell-mediated immunity, not immune complexes, perpetuates ocular inflammation in Behçet's disease.
  • CD4+ T lymphocytes play a central role in Behçet's disease ocular inflammation.

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