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Enteric coated naproxen tablets.

O N Gamst1

  • 1Medical Department, Nycomed Pharma A/S, Oslo 4, Norway.

European Journal of Rheumatology and Inflammation
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Enteric-coated naproxen formulations were developed to reduce topical toxicity in the gastroduodenal lining. While absorption extent remains similar, onset is delayed, especially with food, though gastroscopic benefits are unproven.

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Area of Science:

  • Pharmacology
  • Gastroenterology
  • Drug Delivery Systems

Background:

  • Gastroduodenal mucosal side effects of naproxen are suspected to stem partly from topical toxicity.
  • Enteric-coated aspirin tablets served as a model for developing new naproxen formulations.

Purpose of the Study:

  • To develop enteric-coated naproxen formulations to mitigate gastroduodenal mucosal side effects.
  • To investigate the absorption characteristics and gastrointestinal transit of these new formulations.

Main Methods:

  • Development of enteric-coated naproxen formulations based on enteric-coated aspirin models.
  • Comparative analysis of absorption extent and onset for enteric-coated versus plain naproxen tablets.
  • Investigation of the influence of food intake on gastric emptying of enteric-coated naproxen granules.

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  • Utilizing gamma scintigraphy to study gastrointestinal transit.

    • Main Results:

    • The extent of naproxen absorption was found to be equivalent for both enteric-coated and plain tablets.
    • The onset of absorption was delayed for enteric-coated formulations, particularly when administered with food, due to gastric retention of larger particles.
    • Gastric emptying of enteric-coated naproxen granules showed less influence from food intake.
    • No verified reduction in gastroscopic findings was observed despite formulation modifications.

    Conclusions:

    • Enteric coating delays naproxen absorption onset but does not alter the total extent of absorption.
    • Food intake significantly impacts absorption onset for enteric-coated naproxen.
    • Further research is needed to confirm a reduction in gastroscopic findings with these formulations.