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Related Experiment Videos

Oral naproxen formulations.

O N Gamst1

  • 1Nycomed Pharma, R & D Dept., Oslo, Norway.

Scandinavian Journal of Gastroenterology. Supplement
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Gastric emptying significantly impacts naproxen absorption. Modifying enteric coating pH resistance can delay absorption onset without altering total drug absorption.

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Area of Science:

  • Pharmacokinetics
  • Drug Delivery Systems

Background:

  • Naproxen absorption is influenced by gastric emptying and intestinal dissolution.
  • Enteric-coated formulations exhibit pH-dependent dissolution characteristics.

Purpose of the Study:

  • To investigate the rate-limiting step in naproxen absorption from enteric-coated granules.
  • To explore the impact of enteric coating properties on naproxen absorption profiles.

Main Methods:

  • Oral administration of enteric-coated naproxen granules.
  • Direct duodenal delivery of enteric-coated naproxen granules.
  • Variations in enteric coating to achieve dissolution at different pH levels (4.5-7.0).

Main Results:

  • Oral administration showed delayed absorption, while duodenal delivery resulted in rapid absorption, confirming gastric emptying as rate-limiting.

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  • Dissolution pH of enteric-coated granules could be controlled by adjusting the coating layer.
  • Increased pH resistance of the coating delayed the onset of naproxen absorption.

    • Conclusions:

    • Gastric emptying is the primary determinant of naproxen absorption rate for enteric-coated formulations.
    • Enteric coating properties offer a means to modulate the pharmacokinetic profile of naproxen.
    • Controlled delay in absorption onset is achievable by tailoring enteric coating resistance.