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Related Experiment Videos

Clindamycin and diarrhea.

G D Friedman, M J Gerard, H K Ury

    JAMA
    |November 29, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Diarrhea occurred in 3.4% of outpatients taking clindamycin, a rate consistent with previous research. However, relying only on computer records underestimated diarrhea occurrence in clindamycin users.

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    Area of Science:

    • Infectious Diseases
    • Pharmacology
    • Gastroenterology

    Background:

    • Clindamycin is an antibiotic frequently prescribed for various infections.
    • Diarrhea is a known potential side effect of antibiotic use.
    • Previous studies report a wide range of diarrhea incidence with clindamycin.

    Purpose of the Study:

    • To determine the incidence of diarrhea in outpatients prescribed clindamycin.
    • To compare diarrhea rates between clindamycin users and non-users.
    • To assess the accuracy of computer-recorded data for diarrhea occurrence.

    Main Methods:

    • Retrospective analysis of 298 outpatients receiving clindamycin.
    • Monitoring for diarrhea development and diagnosis of pseudo-membranous colitis.

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  • Comparison of diarrhea rates between antibiotic users and non-users.
  • Evaluation of computer-recorded data versus actual occurrence.

    • Main Results:

    • Diarrhea developed in 3.4% of patients taking clindamycin.
    • No cases of pseudo-membranous colitis were diagnosed.
    • Computer-recorded diarrhea instances significantly underestimated actual occurrence.
    • Diarrhea rates were significantly higher in clindamycin users (P < .05).

    Conclusions:

    • Clindamycin use is associated with a higher incidence of diarrhea compared to non-users.
    • Accurate monitoring of antibiotic-associated diarrhea requires methods beyond computer-recorded data.
    • The incidence of diarrhea in this cohort falls within previously reported ranges.