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Related Experiment Videos

Prognostic factors in node-negative breast cancer.

H Johnson1, S Masood, C Belluco

  • 1Department of Surgery, Long Island Jewish Medical Center, New Hyde Park, NY.

Archives of Surgery (Chicago, Ill. : 1960)
|December 11, 1992
PubMed
Summary

Tumor size, DNA content, and S-phase fraction significantly impact breast cancer survival. Diploid and low S-phase fraction cancers correlate with longer patient survival, highlighting key prognostic factors.

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Area of Science:

  • Oncology
  • Pathology
  • Biostatistics

Background:

  • Breast cancer prognosis is influenced by several factors.
  • Accurate prognostic markers are crucial for patient management.

Purpose of the Study:

  • To investigate the prognostic significance of tumor size, nuclear grade, and DNA content in node-negative breast cancer.
  • To identify key predictors of overall survival.

Main Methods:

  • Analysis of 100 node-negative breast cancer patients.
  • Flow cytometry for DNA content and S-phase fraction determination.
  • Cox proportional hazards model for multivariate analysis.

Main Results:

  • Patients with diploid tumors survived significantly longer (126 months) than those with aneuploid tumors (80 months).

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  • Lower S-phase fraction (<10%) correlated with longer survival (122 months) compared to higher fractions (85 months).
  • Tumor size demonstrated the most significant impact on prognosis, while tumor grade did not significantly affect survival.

    • Conclusions:

    • Tumor size, DNA ploidy, and S-phase fraction are significant prognostic indicators in node-negative breast cancer.
    • Flow cytometry provides valuable information for predicting patient outcomes.
    • Tumor size is the primary determinant of survival in this cohort.