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[Anticardiolipin antibodies--detection and diagnostic value]
Insights
Anticardiolipin antibodies, linked to SLE and other conditions, were found in only 4% of tested SLE patients. This incidence is lower than reported in other studies, with no correlation to disease activity.
Area of Science:
- Immunology
- Rheumatology
- Pathogenesis of autoimmune diseases
Context:
- Anticardiolipin antibodies are associated with systemic lupus erythematosus (SLE), thromboembolic events, thrombocytopenia, and recurrent fetal loss.
- Previous studies indicate a significant prevalence of these antibodies in SLE patients.
Purpose:
- To determine the incidence of anticardiolipin antibodies in a cohort of SLE patients using a modified ELISA technique.
- To investigate potential correlations between anticardiolipin antibodies and disease activity or clinical manifestations like recurrent fetal loss.
Summary:
- A modified ELISA was used to test 53 SLE patient sera for anticardiolipin antibodies.
- Only two sera (4%) tested positive for anticardiolipin antibodies.
- One positive case was associated with recurrent fetal loss and active disease; no correlation with disease activity was found in general.
Impact:
- The study reveals a lower incidence of anticardiolipin antibodies in the tested SLE cohort compared to previous reports.
- Findings may refine understanding of anticardiolipin antibody relevance in specific SLE patient subgroups.
- Highlights the need for further research into regional or population-specific variations in antibody prevalence.
Abstract:
Anticardiolipin antibodies belong to a family of antibodies to phospholid and are important in pathogenesis of some diseases. Statistically significant high titer of circulating anticardiolipin antibodies were found in SLE patients, thromboembolic events, thrombocytopenia and recurrent fetal loss. We tested 53 sera of SLE patients to anticardiolipin antibodies by own modification of ELISA. Only two sera were positive, one of them was associated with recurrent fetal loss and disease. The incidence of anticardiolipin antibodies in we have found no correlation with the activity of to those reported in other studies. Our tested sera (4%) was much lower in comparison.