Related Experiment Video

Updated: Jun 24, 2026

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
09:17

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Published on: January 2, 2017

Nature of colchicine resistance in golden hamster

A R MIDGLEY, B PIERCE, F J DIXON

    Science (New York, N.Y.)
    |July 3, 1959
    PubMed

    Insights

    Golden hamsters are unresponsive to colchicine due to cellular resistance. This resistance allows for in vivo testing of colchicine

    Area of Science:

    • Pharmacology and Toxicology
    • Cancer Research

    Background:

    • Colchicine is a potent anti-mitotic agent.
    • Golden hamsters exhibit inherent resistance to colchicine's toxic effects.

    Purpose of the Study:

    • To investigate the cellular basis of golden hamster colchicine resistance.
    • To establish a model for in vivo colchicine efficacy studies using heterotransplanted tumors.

    Main Methods:

    • Cellular resistance assays to colchicine.
    • Heterotransplantation of tumors into golden hamsters.
    • In vivo administration of colchicine to assess tumor response and host toxicity.

    Main Results:

    • Individual golden hamster cells demonstrate significant resistance to colchicine.
    • Heterotransplanted tumors in colchicine-treated hamsters showed anti-tumor effects.
    • No significant toxic host reactions were observed in the golden hamsters.

    Conclusions:

    • Golden hamster cellular resistance to colchicine is confirmed.
    • This resistance provides a unique model for evaluating colchicine's in vivo anti-tumor activity without systemic toxicity.
    • The model is suitable for preclinical testing of colchicine-based therapies.
    Keywords:
    COLCHICINE/effects

    More Related Videos

    Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method12:03

    Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

    Published on: April 18, 2019

    Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance09:59

    Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance

    Published on: July 21, 2023

    Related Concept Videos

    Antibiotic Selection00:57

    Antibiotic Selection

    Overview
    Antimicrobial Effectiveness01:28

    Antimicrobial Effectiveness

    The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
    Development of Antibiotic Resistance01:30

    Development of Antibiotic Resistance

    Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
    Mechanism of Antibiotic Resistance in MRSA01:25

    Mechanism of Antibiotic Resistance in MRSA

    Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
    Clinical Significance of Antibiotic Resistance01:25

    Clinical Significance of Antibiotic Resistance

    Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...