Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Solvent selection strategies for extractive biocatalysis.

L J Bruce1, A J Daugulis

  • 1Department of Chemical Engineering, Queen's University, Kingston, Ontario, Canada.

Biotechnology Progress
|March 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Current topics in red cell biology: report on the Red Cell Special Interest Group meeting held at NHS Blood and Transplant Bristol on 30 October 2015.

Transfusion medicine (Oxford, England)·2016
Same author

Tropical distal renal tubular acidosis: clinical and epidemiological studies in 78 patients.

QJM : monthly journal of the Association of Physicians·2012
Same author

Two-phase reactors applied to the removal of substituted phenols: comparison between liquid-liquid and liquid-solid systems.

Water science and technology : a journal of the International Association on Water Pollution Research·2010
Same author

Review. Leaky Cl--HCO3- exchangers: cation fluxes via modified AE1.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2008
Same author

Experimental investigation and modeling of oscillatory behavior in the continuous culture of Zymomonas mobilis.

Biotechnology and bioengineering·2008
Same author

Operation of a two-phase partitioning bioreactor for the oxidation of anthracene by the enzyme manganese peroxidase.

Chemosphere·2006
Same journal

Purification and concentration of model viruses using single-pass tangential flow filtration.

Biotechnology progress·2026
Same journal

Advanced glucose control strategies leveraging Raman spectroscopy for optimized mammalian cell culture manufacturing.

Biotechnology progress·2026
Same journal

Mechanistic deconvolution of BSA size variants by constrained Raman pseudo-Voigt hard modeling during anion-exchange chromatography.

Biotechnology progress·2026
Same journal

Status and future of recombinant adeno-associated virus vector manufacturing.

Biotechnology progress·2026
Same journal

Multifaceted algae as an ingredient in alternative meat formulations.

Biotechnology progress·2026
Same journal

In-line Raman spectroscopy real-time glucose prediction method for commercial pneumococcal vaccine drug substance fermentation manufacturing process control.

Biotechnology progress·2026
See all related articles

Researchers developed systematic strategies to screen solvents for improved extraction and biocompatibility. A new computer program, the extractant screening program (ESP), predicts solvent behavior and identifies safe, effective solvent mixtures for various applications.

Area of Science:

  • Green Chemistry and Solvent Engineering
  • Biotechnology and Biocompatibility Assessment
  • Computational Chemistry and Predictive Modeling

Background:

  • Traditional solvent selection often overlooks biocompatibility, leading to potential environmental and health concerns.
  • Identifying effective co-extractants alongside pure solvents is crucial for optimizing extraction processes.
  • Predictive methods for solvent biocompatibility and extractant capability are needed for efficient screening.

Purpose of the Study:

  • To develop systematic strategies for identifying superior pure solvents and effective co-extractants.
  • To introduce and validate methods for predicting solvent biocompatibility and extractant capability.
  • To create a computational tool for predicting solvent/aqueous system behavior.

Main Methods:

Related Experiment Videos

  • Development of heuristic data and correlative models to predict solvent biocompatibility based on bioactivity, partition coefficients, and cell membrane concentration.
  • Creation of the extractant screening program (ESP), a computer-aided tool for predicting product behavior in solvent/aqueous systems.
  • Experimental validation of solvent mixtures combining biocompatible and toxic solvents to achieve desired extractant properties while maintaining biocompatibility.

Main Results:

  • Successful prediction of solvent biocompatibility using established data and novel correlations.
  • Demonstration that mixing a poor but biocompatible solvent with a toxic, effective solvent can yield a mixture with improved characteristics.
  • Identification of solvent mixtures with enhanced biocompatibility, even at higher concentrations of toxic components, by exploiting non-ideal mixing behavior.

Conclusions:

  • Systematic solvent screening strategies can effectively identify superior pure solvents and co-extractants.
  • The extractant screening program (ESP) provides a powerful computational approach for predicting and optimizing solvent systems.
  • Tailored solvent mixtures offer a viable route to achieving high extraction efficiency while ensuring biocompatibility.