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Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion
08:19

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Published on: January 15, 2016

Independent walking after neonatal arterial ischemic stroke and sinovenous thrombosis

Meredith R Golomb1, Gabrielle A deVeber, Daune L MacGregor

  • 1Department of Neurology, Division of Pediatric Neurology, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN 46202, USA. mgolomb@iupui.edu

Journal of Child Neurology
|September 19, 2003
PubMed

Insights

Most infants surviving neonatal stroke walk independently. Bilateral strokes, however, significantly reduce the likelihood of achieving this milestone, though parental reports often indicate normal gait.

Area of Science:

  • Neurology
  • Pediatrics
  • Developmental Pediatrics

Background:

  • Neonatal arterial ischemic stroke (NAIS) and sinovenous thrombosis (NSVT) are serious conditions affecting newborns.
  • Limited research exists on the long-term motor development, specifically walking, following these neonatal cerebrovascular events.

Purpose of the Study:

  • To investigate the probability and timing of independent walking in neonates with NAIS or NSVT.
  • To identify factors, including stroke type and extent, that predict walking ability and gait normality.

Main Methods:

  • Retrospective cohort study of 88 term and near-term neonates with NAIS or NSVT.
  • Kaplan-Meier curves and Cox proportional hazards models analyzed predictors of independent walking.
  • Chi-square tests assessed predictors of parent-reported normal gait.

Main Results:

  • 90.4% of survivors achieved independent walking, with a median age of 13 months.
  • Only bilateral cerebral infarctions were associated with a significantly lower probability of initiating independent walking (HR=0.41, P=0.04).
  • Parents reported normal gait in 77.3% of walkers; no studied variable predicted this normality.

Conclusions:

  • Most infants surviving NAIS and NSVT achieve independent walking, often with a gait perceived as normal by parents.
  • Bilateral brain involvement in neonatal stroke is a key risk factor for delayed or absent independent walking.
  • Further research may explore objective gait assessments beyond parental reporting.

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