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Oxidosqualene cyclase inhibitors as antimicrobial agents
Jerald C Hinshaw1, Dae-Yeon Suh, Philippe Garnier
1Department of Medicinal Chemistry, University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, Utah 84108-1257, USA.
Journal of Medicinal Chemistry
|September 19, 2003
Abstract:
Small-molecule oxidosqualene cyclase (OSC) inhibitors were found to be effective in assays against cloned OSC-like enzymes from human pathogens. A combinatorial library was prepared and used to identify lead compounds that inhibit the growth of Trypanosoma cruzi, Leishmania mexicana amazonensis, and Pneumocystis carinii in culture. Selectivity for the microorganisms in preference to mammalian cells was observed.