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Updated: Aug 17, 2026
An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
Published on: November 2, 2016
Structural characterization of a dipeptide compound with immunostimulant activity:
R Artali1, G Bombieri, F Meneghetti
1Istituto di Chimica Farmaceutica e Tossicologica, Viale Abruzzi, 42, I-20131 Milano, Italy.
Abstract:
The structural characteristics of an immunostimulating agent (3-(5-thioxo-L-prolyl)-L-thiazolidine-4-carboxylic acid) have been established using a combination of 1H and 13C NMR spectroscopy, molecular mechanic calculations (in vacuo and in solution) and X-ray crystallographic analyses. Conformational calculations and NMR spectra identify two classes of conformers, cis and trans, around the peptide bond between the rings, while in the solid state only the cis form has been found.
