Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gene therapy techniques.

F Levine1, T Friedmann

  • 1University of California, School of Medicine, San Diego, La Jolla.

Current Opinion in Biotechnology
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

Gene therapy clinical trials have begun, introducing genetically altered cells for cancer and adenosine deaminase deficiency. Advances in gene transfer technology support these groundbreaking human treatments.

Related Experiment Videos

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gene therapy for spinomuscular atrophy: a biomedical advance, a missed opportunity for more equitable drug pricing.

Gene therapy·2017
Same author

Pharmacological induction of pancreatic islet cell transdifferentiation: relevance to type I diabetes.

Cell death & disease·2014
Same author

Spinal interaction between the highly selective μ agonist DAMGO and several δ opioid receptor ligands in naive and morphine-tolerant mice.

Brain research bulletin·2012
Same author

Antipsychotics activate the TGFβ pathway effector SMAD3.

Molecular psychiatry·2012
Same author

Localization of hypoxanthine-guanine phosphoribosyltransferase mRNA in the mouse brain by in situ hybridization.

Molecular and cellular neurosciences·2009
Same author

Adult human beta-cell neogenesis?

Diabetes, obesity & metabolism·2009
Same journal

Microbial C1 assimilation pathways for chemical synthesis: from native metabolism to synthetic design.

Current opinion in biotechnology·2026
Same journal

Medicinal plants fermentation: current knowledge and perspectives.

Current opinion in biotechnology·2026
Same journal

Fermented foods: lessons learned from metagenomics.

Current opinion in biotechnology·2026
Same journal

Microfluidic platforms for the transient transfection of mammalian cells: recent developments and challenges.

Current opinion in biotechnology·2026
Same journal

Harvesting insights from recent advances in yeast genomics for predictable and precision wine fermentation.

Current opinion in biotechnology·2026
Same journal

Minimal enzyme cascades for the aromatic-to-aromatic upgrading of lignin monomers.

Current opinion in biotechnology·2026
See all related articles

Area of Science:

  • Biotechnology
  • Genetics
  • Medical Research

Background:

  • Gene therapy represents a significant advancement in medical treatment.
  • Clinical applications are expanding, moving from theoretical to practical implementation.

Purpose of the Study:

  • To review the recent initiation of gene therapy clinical trials.
  • To highlight progress in gene transfer technology relevant to gene therapy.

Main Methods:

  • Initiation of clinical trials involving genetically altered cells.
  • Development of gene transfer technologies.

Main Results:

  • Four clinical trials are underway: three for cancer therapy and one for adenosine deaminase deficiency.
  • Significant progress has been made in gene transfer technology.

Conclusions:

  • The field of gene therapy is rapidly advancing with the commencement of human clinical trials.
  • Technological progress in gene transfer is crucial for the success of gene therapy applications.