Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Radiation nephropathy.

Eric P Cohen1, Mike E C Robbins

  • 1Medical College of Wisconsin, Milwaukee, WI, USA.

Seminars in Nephrology
|September 19, 2003
PubMed
Summary
This summary is machine-generated.

Radiation nephropathy, a kidney injury from radiotherapy, can cause renal failure. Targeting the renin-angiotensin system (RAS) shows promise for treating this condition, even after radiation exposure.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cosmic Kidney Disease: Countermeasures to Attenuate Kidney Damage in Space.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

Regarding "The Efficacy and Safety of Technology-Guided Dry Weight Adjustment Among Dialysis Patients: A Meta-Analysis of Randomized Controlled Trials" by Wathanavasin et al.

Kidney medicine·2026
Same author

Dialysis.

JAMA·2025
Same author

Stenosis of the glomerulotubular neck in progressive chronic kidney disease.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2024
Same author

A New Method for Estimating Glomerular Filtration Rate in Rhesus Macaques (Macaca mulatta).

Radiation research·2023
Same author

The Reply.

The American journal of medicine·2023
Same journal

Current Options for Kidney Protection: Are Renin-Angiotensin System Inhibitors Still Relevant?

Seminars in nephrology·2026
Same journal

Proposed Role for Quantitative Podocyturia as a Clinical Marker of Systemic Endothelial Injury: Implications for Cardiovascular Disease and Longevity.

Seminars in nephrology·2026
Same journal

Kidney Protection Options in 2025: Are Renin-Angiotensin System Inhibitors Still Needed?

Seminars in nephrology·2026
Same journal

From Nephron Number to Global Health.

Seminars in nephrology·2026
Same journal

Chronic Kidney Disease Progression Mechanisms: Why They Matter in an Era of Novel Kidney Protective Therapies.

Seminars in nephrology·2026
Same journal

Of Diuretics, Transporters, and Mechanisms of Hypertension.

Seminars in nephrology·2026
See all related articles

Area of Science:

  • Nephrology
  • Radiation Oncology
  • Oncology

Background:

  • Renal tissue's radiosensitivity restricts radiotherapy doses, increasing radiation nephropathy risk.
  • Radiation nephropathy incidence rises with total-body irradiation (TBI) and radionuclide therapies.
  • Clinical presentation includes azotemia, hypertension, anemia, and potential renal failure.

Purpose of the Study:

  • To explore the pathophysiology of radiation nephropathy.
  • To investigate the role of the renin-angiotensin system (RAS) in radiation nephropathy.
  • To assess the therapeutic potential of RAS antagonism in radiation nephropathy.

Main Methods:

  • Review of clinical and experimental studies on radiation nephropathy.
  • Analysis of structural changes in irradiated renal tissue.

Related Experiment Videos

  • Examination of the biological mediators involved in nephron injury and repair.

    • Main Results:

    • Radiation nephropathy involves complex cellular interactions beyond direct DNA damage.
    • The renin-angiotensin system (RAS) plays a significant role in radiation-induced kidney injury.
    • Experimental studies demonstrate beneficial effects of RAS antagonism, even when initiated post-irradiation.

    Conclusions:

    • Radiation nephropathy is a complex process involving multiple cell types and mediators.
    • RAS antagonism is a promising therapeutic strategy for radiation nephropathy.
    • RAS antagonism may offer benefits in clinical radiation nephropathy cases.