Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Retroelement particles as purification, presentation and targeting vehicles.

A J Kingsman1, S E Adams, N R Burns

  • 1Virus Molecular Biology Group, Department of Biochemistry, Oxford, UK.

Trends in Biotechnology
|September 1, 1991
PubMed
Summary

Engineered retrotransposon and retroviral particles can now carry active molecules and target specific cells. This breakthrough has significant potential for gene therapy, drug delivery, and vaccine development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Architecture and regulation of a GDNF-GFRα1 synaptic adhesion assembly.

Nature communications·2023
Same author

Decreased neonatal morbidity in 'stomach-down' left congenital diaphragmatic hernia: implications of prenatal ultrasound diagnosis for counseling and postnatal management.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2021
Same author

Variability of nonpathogenic influenza virus H5N3 under immune pressure.

Acta virologica·2020
Same author

Conformationally restricted calpain inhibitors.

Chemical science·2017
Same author

A randomised clinical study to determine the effect of a toothpaste containing enzymes and proteins on plaque oral microbiome ecology.

Scientific reports·2017
Same author

The influence of motor function on processing speed in preterm and term-born children.

Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence·2015

Area of Science:

  • Molecular biology
  • Biotechnology
  • Virology

Background:

  • Retroviral and retrotransposon vectors are being explored for therapeutic applications.
  • Current research focuses on enhancing their payload capacity and targeting specificity.

Purpose of the Study:

  • To investigate the feasibility of engineering retrotransposon and retroviral particles for molecular delivery.
  • To explore the potential of targeted delivery of these engineered particles to specific cell types.

Main Methods:

  • Particle engineering for payload incorporation.
  • Cellular targeting strategies development.
  • In vitro and in vivo validation of particle function.

Main Results:

Related Experiment Videos

  • Demonstrated feasibility of retrotransposon and retroviral particle manipulation for carrying biologically active molecules.
  • Experimental evidence suggests successful targeting of engineered particles to specific cell types.

    • Conclusions:

    • Engineered retrotransposon and retroviral particles show promise for advanced gene therapy.
    • These particles offer potential for targeted biological drug delivery and novel vaccine design.