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Neutrophil adhesion: a point for therapeutic intervention?
1Inflammation Biology Group, Celltech Research Ltd, Slough, Berkshire, UK.
Current Opinion in Biotechnology
|December 1, 1992
Summary
Compounds interfering with intercellular adhesion can modulate inflammatory responses. This review focuses on neutrophil extravasation adhesion interactions and potential disruption strategies.
Area of Science:
- Immunology
- Cell Biology
- Pharmacology
Background:
- Inflammation involves complex cellular interactions.
- Intercellular adhesion plays a critical role in inflammatory processes.
- Modulating these adhesion pathways offers therapeutic potential.
Purpose of the Study:
- To review adhesion interactions during neutrophil extravasation.
- To explore strategies for disrupting these adhesion mechanisms.
- To highlight the potential of targeting intercellular adhesion in inflammatory diseases.
Main Methods:
- Literature review of studies on neutrophil extravasation.
- Analysis of molecular mechanisms of intercellular adhesion.
- Identification of potential therapeutic targets.
Main Results:
- Neutrophil extravasation relies on specific adhesion molecule interactions.
- Several molecular targets for disrupting these interactions have been identified.
- Compounds interfering with adhesion show promise in preclinical models.
Conclusions:
- Targeting intercellular adhesion is a viable strategy for controlling inflammation.
- Further research into adhesion modulators could lead to novel anti-inflammatory therapies.
- Understanding these interactions is key to developing new treatments for inflammatory conditions.