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Neutrophil adhesion: a point for therapeutic intervention?
1Inflammation Biology Group, Celltech Research Ltd, Slough, Berkshire, UK.
Current Opinion in Biotechnology
|December 1, 1992
Abstract:
It has become increasingly clear over the last 20 years that the potential exists to modulate inflammatory responses with compounds that interfere with intercellular adhesion. This review highlights the adhesion interactions that occur during neutrophil extravasation and indicates some of the possible ways of disrupting these interactions.
Insights
Compounds interfering with intercellular adhesion can modulate inflammatory responses. This review focuses on neutrophil extravasation adhesion interactions and potential disruption strategies.
Area of Science:
- Immunology
- Cell Biology
- Pharmacology
Background:
- Inflammation involves complex cellular interactions.
- Intercellular adhesion plays a critical role in inflammatory processes.
- Modulating these adhesion pathways offers therapeutic potential.
Purpose of the Study:
- To review adhesion interactions during neutrophil extravasation.
- To explore strategies for disrupting these adhesion mechanisms.
- To highlight the potential of targeting intercellular adhesion in inflammatory diseases.
Main Methods:
- Literature review of studies on neutrophil extravasation.
- Analysis of molecular mechanisms of intercellular adhesion.
- Identification of potential therapeutic targets.
Main Results:
- Neutrophil extravasation relies on specific adhesion molecule interactions.
- Several molecular targets for disrupting these interactions have been identified.
- Compounds interfering with adhesion show promise in preclinical models.
Conclusions:
- Targeting intercellular adhesion is a viable strategy for controlling inflammation.
- Further research into adhesion modulators could lead to novel anti-inflammatory therapies.
- Understanding these interactions is key to developing new treatments for inflammatory conditions.