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Updated: Aug 19, 2026

Analysis of Cell Cycle Position in Mammalian Cells
Published on: January 21, 2012
The retinoblastoma protein and cell cycle regulation
P A Hamel1, B L Gallie, R A Phillips
1Department of Medical Genetics, University of Toronto, Canada.
Abstract:
Although the precise function of the retinoblastoma gene product, p110RB1, remains unknown, recent data suggest that it plays a role in the control of cellular proliferation by regulating transcription of genes required for a cell to enter or stay in a quiescent or G0 state, or for progression through the G1 phase of the cell cycle. However, it is difficult to rationalize the expression of p110RB1 in a wide range of tissues with the fact that mutations in the RB1 gene initiate cancers in a limited number of tissues.
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