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Virus isolated from inclusion conjunctivitis of newborn (inclusion blennorrhea)

L HANNA, J ZICHOSCH, E JAWETZ

    Science (New York, N.Y.)
    |December 2, 1960
    PubMed

    Insights

    A novel virus causing infant conjunctivitis was isolated from an infant's eye discharge. This agent, resembling trachoma virus, successfully induced similar symptoms in monkey eyes.

    Area of Science:

    • Ophthalmology
    • Virology
    • Neonatal Medicine

    Background:

    • Acute conjunctivitis is a common neonatal infection.
    • Inclusion conjunctivitis in infants can be caused by Chlamydia trachomatis.
    • The etiology of some conjunctivitis cases remains unclear.

    Purpose of the Study:

    • To identify the causative agent of acute conjunctivitis in a neonate.
    • To characterize the isolated pathogen and its potential to cause disease.

    Main Methods:

    • Microscopic examination of conjunctival discharge for elementary-body inclusions.
    • Viral culture from conjunctival scrapings using embryonated eggs.
    • Experimental induction of conjunctivitis in monkey eyes.

    Main Results:

    • Typical elementary-body inclusions were observed in the infant's discharge.
    • A virus, similar to trachoma virus, was successfully isolated and cultured.
    • Instillation of the cultured virus into monkey eyes caused acute conjunctivitis.

    Conclusions:

    • A viral agent, distinct from Chlamydia, was implicated in this case of infant conjunctivitis.
    • The isolated virus demonstrated pathogenicity in an animal model.
    • Further investigation is needed to understand the prevalence and characteristics of this viral pathogen.

    Keywords:
    CONJUNCTIVITIS/in infancy and childhoodINFANT, NEWBORN/diseasesVIRUS DISEASES/in infancy and childhood

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