[Influence of normovolemic hemodilution on the respiratory and circulatory systems]

We studied respiratory and circulatory kinetics of normovolemic hemodilution in adult mongrel dogs. The dogs were divided into two groups; Dextran-40 (group A) and SALIN-HES (group B). No difference in PaO2 and PaCO2 was noted between the two groups. MPA and CI during normovolemic hemodilution were higher in group A than in group B. However, MPA, Qs/Qt and ETVI during normovolemic hemodilution were largely influenced in group A. L/P during normovolemic hemodilution was more influenced in group B than in group A. The compensatory effect with increase of the cardiac output during normovolemic hemodilution was noted until S3 (Hct = 10%), but it was not noted at S4 (Hct = 5%) and S5 (just before death). SvO2 is the most sensitive index indicating the risk of normovolemic hemodilution.