Related Experiment Video
Updated: Aug 10, 2026

Dextran Enhances the Lentiviral Transduction Efficiency of Murine and Human Primary NK Cells
Published on: January 15, 2018
Dextran antibodies, complement conversion and circulating immune complexes after intravenous iron dextran therapy in
L W Fleming1, W K Stewart, D Parratt
1Department of Medicine, University of Dundee, Ninewells Hospital and Medical School, Scotland, UK.
Iron dextran infusions in dialysis patients did not affect immune complexes or complement conversion. Dextran antibodies temporarily disappeared post-infusion, and their presence does not prevent iron dextran administration.
Area of Science:
- Immunology
- Nephrology
- Pharmacology
Background:
- Intravenous iron dextran is used for anemia in dialysis patients.
- Potential immunogenic reactions to iron dextran exist.
Purpose of the Study:
- To investigate the immunologic effects of iron dextran infusions in dialysis patients.
- To assess changes in serum immune complexes, dextran antibodies, and complement conversion.
Main Methods:
- 20 dialysis patients received 600 mg elemental iron via intravenous iron dextran.
- Measurements of immune complexes, dextran antibodies, and complement conversion were taken before and after infusion.
Main Results:
- No significant changes in immune complexes or complement conversion were observed.
- Dextran antibodies became undetectable hours after infusion, reappearing in some patients after 1 month.
- Mild adverse reactions (aches, shivers) and one case of joint inflammation were not clearly linked to dextran antibodies or the measured immune parameters.
Conclusions:
- The presence of dextran antibodies does not contraindicate iron dextran use in dialysis patients.
- Iron dextran infusions do not appear to disturb the immune complex and complement systems.
More Related Videos
05:23Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
09:12A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
Published on: June 15, 2018
Related Concept Videos
Humoral Immune Responses
Transcytosis of IgG
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
EDTA: Auxiliary Complexing Reagents
Antimicrobial Proteins
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Antibody Actions
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
Hypersensitivity Reactions: Cytolytic Reactions