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Updated: Jul 27, 2026

HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL
Published on: April 11, 2011
Huntington's disease: delayed hypersensitivity in vitro to human central nervous system antigens
Abstract:
Huntington's disease is a hereditary, chronic, degenerative disease of the brain which is transmitted by an autosomal dominant gene. We have discovered that lymphocytes from patients with Huntington's disease respond to the presence of brain tissue from patients with the disease by producing migration inhibition factor, a correlate of the cellular immune response. Lymphocytes from donors without the disease do not respond to the diseased brain tissue, and lymphocytes from patients with Huntington's disease respond only rarely to brain tissue from donors without the disease.
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