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Delayed onset of epidermal differentiation in psoriasis
F Bernerd1, T Magnaldo, M Darmon
1Centre International de Recherches Dermatologiques Galderma (CIRD Galderma), Valbonne, France.
The Journal of Investigative Dermatology
|June 1, 1992
Summary
Psoriatic epidermis shows delayed keratinocyte differentiation, with early markers absent in basal layers. This indicates abnormalities extend beyond suprabasal layers in psoriasis.
Area of Science:
- Dermatology
- Cell Biology
- Molecular Biology
Background:
- Normal epidermis exhibits early keratinocyte differentiation markers (K1, K10) in basal and suprabasal layers.
- Psoriasis is characterized by altered epidermal differentiation, though specific changes in early markers remain debated.
Purpose of the Study:
- To investigate the precise distribution of early differentiation markers (K1, K10, K5 keratins) in psoriatic epidermis.
- To determine if abnormalities in psoriatic epidermis are confined to suprabasal layers or also affect the basal layer.
Main Methods:
- Analysis of keratin K1, K10, and K5 transcript and protein expression in normal and psoriatic epidermis.
- Comparison of marker distribution at the periphery and center of psoriatic lesions.
Main Results:
- Psoriatic basal layers lack early differentiation markers (K1, K10), unlike normal epidermis.
- K10 expression is absent in suprabasal and upper epidermal layers in psoriatic lesions.
- K5 keratin transcripts persist in suprabasal layers of psoriatic epidermis, extending beyond normal distribution.
Conclusions:
- The onset of keratinocyte differentiation is delayed in psoriasis.
- Psoriatic epidermis exhibits qualitative differences in keratin marker distribution, affecting both basal and suprabasal compartments.
- These findings challenge previous assumptions about the normalcy of the basal layer in psoriatic epidermis.