Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Surface markers, heavy chain sequences and B cell lineages.

H H Wortis1

  • 1Department of Pathology, Tufts University School of Medicine, Boston, MA.

International Reviews of Immunology
|January 1, 1992
PubMed
Summary

A new theory explains B cell development, distinguishing fetal and adult B cell lineages. Fetal B cells expressing CD5 are linked to natural autoantibodies, while adult B cells have different activation pathways.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cutting edge commentary: origins of B-1 cells.

Journal of immunology (Baltimore, Md. : 1950)·2001
Same author

Role of NFAT in the regulation of B-1 cells.

Current topics in microbiology and immunology·2000
Same author

A model for autoantigen induction of natural antibody producing B-1a cells.

Current topics in microbiology and immunology·2000
Same author

Bruton's tyrosine kinase links the B cell receptor to nuclear factor kappaB activation.

The Journal of experimental medicine·2000
Same author

Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton's tyrosine kinase.

Molecular and cellular biology·1999
Same author

The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins.

Molecular and cellular biology·1998

Area of Science:

  • Immunology
  • Cell Biology
  • Developmental Biology

Background:

  • Two distinct B cell lineages exist: fetal-derived (no N insertions) and adult-derived (N-containing).
  • B cell commitment to CD5 expression and long-life capacity is influenced by B cell receptor (BCR) signaling.

Purpose of the Study:

  • To present a unifying theory of B cell development and lineage commitment.
  • To explain the differential induction of CD5 expression in fetal versus adult B cells.
  • To provide a model for understanding natural autoantibody production.

Main Methods:

  • Theoretical model based on existing literature and experimental data.
  • Analysis of B cell receptor (BCR) signaling pathways.
  • Comparison of BCR repertoire differences between fetal and adult B cells.

Main Results:

  • Fetal B cells, upon stimulation with thymus-independent type two antigens, commit to CD5 expression and self-renewal.
  • Adult B cell activation via T cell interaction does not induce CD5 and results in lower J11d expression.
  • Differences in immunoglobulin (Ig) repertoire likely drive CD5 induction in fetal/neonatal B cells.

Conclusions:

  • The proposed model explains the correlation between CD5 expression and natural autoantibody production in neonatal B cells.
  • This framework offers insights into the origins of pathogenic autoantibodies.
  • The theory unifies understanding of B cell lineage commitment and function.

Related Experiment Videos