A study on delayed hypersensitivity to rotavirus in infancy and childhood

The T-cell responsiveness to rotavirus antigen and phytohaemagglutinin (PHA) together with T-cell total and subsets quantitation was carried out in 50 non-diarrhoeal and six rotavirus diarrhoeal subjects. All individuals in the non-diarrhoeal group responded well to PHA and had normal values for T-cell subsets. The number of positive responders to the rotavirus antigen increased gradually from 0% in the newborns to 92% in older children. The increasing risk of exposure to rotavirus infection is thought to be a chief cause of this age-related variation. All the rotavirus diarrhoeal patients responded well to the rotavirus antigen, indicating a potent test system. The T-cell responses to PHA and the T-cell subsets were significantly low. This could be due to temporary T-cell suppression that may accompany viral infection. Our results are discussed in the context of previous studies.