Related Experiment Videos
[CSF monoamine metabolites in patients with progressive supranuclear palsy]
M Yamamoto1, H Ujike, I Kohira
1Department of Neurology, Kagawa Central Hospital.
Rinsho Shinkeigaku = Clinical Neurology
|March 1, 1992
Abstract:
Neurochemical abnormalities in the patients with progressive supranuclear palsy (PSP) are not well understood. We investigated CSF levels of the monoamine metabolites HVA, 5HIAA and MHPG in 5 patients with PSP in order to investigate, especially dopaminergic, serotonergic and noradrenergic metabolism. Results were as follows (value; mena +/- S.D.). [table: see text] The levels of HVA were significantly lower than those in controls. These findings suggest that there is a hypofunction of dopaminergic neurons in PSP patients.