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Interleukin-8 inhibits the induction of nitric oxide synthase in rat peritoneal neutrophils
T B McCall1, R M Palmer, S Moncada
1Wellcome Research Laboratories, Beckenham, Kent, U.K.
Biochemical and Biophysical Research Communications
|July 31, 1992
Abstract:
The effect of interleukin(IL)-8 and leukotriene B4 (LTB4) on the induction of nitric oxide (NO) synthase in rat peritoneal neutrophils (PMN) ex vivo was studied. IL-8, but not LTB4, caused concentration-dependent inhibition of the induction of a Ca(2+)-independent NO synthase ex vivo. The effect of IL-8 was not attributable to the synthesis of an inhibitor of this enzyme. These findings suggest complex regulatory control of the induction of NO synthase by cytokines.