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An immunohistochemical study on HLA-DR expression in human meningiomas
1Second Department of Pathology, Okayama University Medical School, Japan.
Acta Neuropathologica
|January 1, 1992
Summary
Meningioma tumor cells express HLA-DR, particularly in transitional and fibrous subtypes. This aberrant expression in tumor cells shows little correlation with lymphoid cell infiltration.
Area of Science:
- Immunology
- Oncology
- Neuropathology
Background:
- Human Leukocyte Antigen-DR (HLA-DR) is a key molecule in immune responses.
- Meningiomas are primary tumors of the central nervous system, arising from meningeal cells.
- Understanding tumor cell antigen expression is crucial for comprehending tumor-host interactions.
Purpose of the Study:
- To investigate the expression of HLA-DR on tumor cells in meningiomas.
- To correlate HLA-DR expression with meningioma subtypes and lymphoid infiltration.
Main Methods:
- Analysis of 38 meningioma specimens using streptavidin-biotin immunoperoxidase staining.
- Utilized two monoclonal antibodies (LN-3 and TAL-IB5) for HLA-DR detection.
- Examined formalin-fixed, paraffin-embedded tissue samples.
Main Results:
- Tumor cells expressed HLA-DR in 42% of meningioma cases.
- Higher HLA-DR expression rates were observed in transitional (64%) and fibrous (67%) subtypes compared to meningotheliomatous (8%) subtype.
- Spindle-shaped tumor cells were more frequently HLA-DR positive than plump meningothelial cells.
- HLA-DR expression on tumor cells showed minimal correlation with the degree of lymphoid cell infiltration.
Conclusions:
- Meningioma tumor cells exhibit aberrant HLA-DR expression.
- This expression pattern varies significantly across different meningioma subtypes.
- Tumor cell HLA-DR expression is largely independent of the extent of lymphoid cell infiltration in the tumor microenvironment.