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Effect of long-term use of Norplant implants on haemostatic function
1Department of Obstetrics and Gynaecology, National University of Singapore, National University Hospital, Singapore.
Contraception
|March 1, 1992
Abstract:
This study describes the effects of Norplant on haemostatic function after 5 years of use in 97 women. There was a decrease in vitamin-K dependent Factors II, V, VII and reduction in fibrinolytic activity at 2 and 4 years of use. Increased platelet numbers and accelerated platelet aggregation were found throughout the 5 years of Norplant use, whilst raised alpha 2-Macroglobulin (a2-M) and antithrombin III (ATIII) antigen level were observed for up to 4 years of use. Prolonged Norplant use does not appear to activate the coagulation system and does not enhance a state of hypercoagulation.
Keywords:
AsiaBiologyBlood Coagulation EffectsContraceptionContraceptive ImplantsContraceptive MethodsDemographic FactorsDeveloping CountriesFamily PlanningFibrinolysisHematological EffectsHemic SystemHemoglobin LevelPhysiologyPlatelet AggregationPopulationPopulation DynamicsResearch ReportSingaporeSoutheastern AsiaTime Factors