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Related Experiment Videos

Diffusion of tosufloxacin into prostatic tissue.

T Uchibayashi1, H Hisazumi, J Kanayama

  • 1Department of Urology, School of Medicine, Kanazawa University, Japan.

Chemotherapy
|January 1, 1992
PubMed
Summary

Tosufloxacin (TFLX) effectively penetrates prostatic tissue, achieving concentrations above bacterial minimum inhibitory levels. This fluoroquinolone shows potential for treating bacterial prostatitis and post-surgical infections.

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Area of Science:

  • Pharmacology
  • Urology
  • Infectious Diseases

Background:

  • Bacterial prostatitis and post-surgical infections are significant clinical challenges.
  • Understanding antibiotic penetration into prostatic tissue is crucial for effective treatment.

Purpose of the Study:

  • To investigate the diffusion and concentration of tosufloxacin (TFLX) in prostatic tissue.
  • To evaluate the potential of TFLX for treating bacterial prostatitis and related infections.

Main Methods:

  • A study involving 25 patients with benign prostatic hypertrophy undergoing surgery.
  • Oral administration of 450 mg TFLX pre-surgery and 150 mg immediately before surgery.
  • Measurement of TFLX concentrations in serum and prostatic tissue at 2, 4, and 6 hours post-administration.

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Main Results:

  • Mean TFLX levels in prostatic tissue ranged from 0.22 to 0.58 microgram/g at different time points.
  • Prostatic tissue to serum concentration ratios ranged from 0.93 to 1.10.
  • Achieved TFLX levels in prostatic tissue exceeded the minimum inhibitory concentration for common pathogens.

Conclusions:

  • Tosufloxacin demonstrates significant diffusion into prostatic tissue.
  • TFLX concentrations achieved are sufficient to inhibit key bacterial pathogens.
  • Tosufloxacin holds promise for treating bacterial prostatitis and post-prostatectomy infections.