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Published on: July 17, 2014
The relationship of serum gamma-globulin concentration to malaria and sickling
Journal of Clinical Pathology
|March 1, 1960
Abstract:
The serum protein patterns of groups of Nigerians including 98 children partially protected by "daraprim" against malaria, and 113 unprotected children, have been studied. The protected children have a significantly lower concentration of serum gamma globulin than the unprotected children from the age of 12 months onwards. In children, sicklers have a significantly higher serum gamma globulin than non-sicklers. It is suggested that sickling protects against malaria by enhancing the antibody response against the malaria parasite.
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