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Acute phase reactants in predicting disease outcome.

D Thompson, J T Whicher, R E Banks

    Bailliere'S Clinical Rheumatology
    |June 1, 1992
    PubMed
    Summary
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    Initial acute phase response findings in early inflammatory arthritis, including rheumatoid arthritis, show limited predictive value for patient outcomes or mortality. Variability in measurements further reduces their clinical usefulness as predictors of disease progression.

    Area of Science:

    • Rheumatology
    • Immunology
    • Clinical Medicine

    Background:

    • The acute phase response is a key indicator of inflammation.
    • Early inflammatory arthritis, especially rheumatoid arthritis, involves complex inflammatory processes.
    • Predicting functional outcome and mortality in these conditions is clinically significant.

    Purpose of the Study:

    • To evaluate the predictive value of initial acute phase response findings in early inflammatory arthritis.
    • To assess the clinical utility of acute phase reactants in predicting disease outcome and mortality.
    • To explore the potential of trends in acute phase reactants for indicating disease activity.

    Main Methods:

    • Review of existing studies on acute phase response in early inflammatory arthritis.

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  • Analysis of initial measurements of acute phase reactants.
  • Assessment of correlation between acute phase response and functional outcome/mortality.

    • Main Results:

    • Initial acute phase response findings have minimal predictive power for functional outcome or mortality in early inflammatory arthritis.
    • Significant interindividual variability in acute phase measurements limits their use as predictors.
    • Limited evidence suggests trends in some acute phase reactants might indicate disease activity, but more research is needed.

    Conclusions:

    • Initial acute phase response measurements are not reliable predictors of long-term outcomes in early inflammatory arthritis.
    • Clinical utility of acute phase reactants is constrained by variability and lack of predictive accuracy.
    • Further investigation into the trend of acute phase reactants is warranted to assess their role in monitoring disease activity.