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[Hyperthermia for cancer with dextran magnetite using tubular implants]
S Takemori1, K Tazawa, H Nagae
1Second Dept. of Surgery, Faculty of Medicine, Toyama Medical and Pharmaceutical University.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|August 1, 1992
Summary
Dextran magnetite (DM) implants enable targeted cancer hyperthermia. Inductive heating of these nanoparticles selectively raised temperatures, suggesting potential for diverse cancer treatments.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Dextran magnetite (DM) particles are aqueous nanometer complexes of iron oxide cores coated with dextran chains.
- These particles can be formulated into injectable aqueous zols for medical applications.
Purpose of the Study:
- To investigate the feasibility of using DM implants for localized hyperthermia in cancer treatment.
- To evaluate the temperature elevation and heating area achieved using inductive electromagnetic fields with DM implants.
Main Methods:
- DM aqueous zol was encapsulated within polyester tubes to create implants.
- Implants were placed in an agar phantom, and temperature changes were measured under an inductive electromagnetic field (500 kHz, 7 kW generator).
- Heating parameters, including inductive power, number of implants, and arrangement, were varied to assess their effects.
Main Results:
- Inductive heating at 2.6 kW elevated the temperature by 3.4 degrees Celsius at 5 mm from the implant.
- An area of 20 x 20 mm was effectively heated.
- Selective heating of the target area was demonstrated.
Conclusions:
- Inductive heating of DM implants at 500 kHz is a viable method for localized hyperthermia.
- The customizable nature of DM zol implants allows for potential application in treating various cancers.
- This technique shows promise for selective cancer treatment through targeted hyperthermia.