Related Experiment Videos
Reduction of CSF monoamine metabolites in poststroke depression: a preliminary report
J B Bryer1, S E Starkstein, V Votypka
1Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
The Journal of Neuropsychiatry and Clinical Neurosciences
|January 1, 1992
Abstract:
Monoamine metabolites were measured in the cerebrospinal fluid (CSF) of depressed and nondepressed patients with acute stroke lesions and in nondepressed patients without stroke lesions. Depressed stroke patients had a significantly lower concentration of CSF 5-hydroxyindoleacetic acid (5-HIAA; a serotonin metabolite) than the other two groups. These findings suggest that poststroke depression may be mediated by serotonergic mechanisms.