Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Contact allergy to tioconazole.

S Stubb1, H Heikkilä, S Reitamo

  • 1Department of Dermatology, Helsinki University Central Hospital, Finland.

Contact Dermatitis
|March 1, 1992
PubMed
Summary

Allergic reactions to the antifungal tioconazole were observed in 14 patients over 15 months. Many patients also reacted to similar antifungals, suggesting cross-reactivity due to shared chemical structures.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hereditary palmoplantar keratoderma - phenotypes and mutations in 64 patients.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

Atopic dermatitis management with tacrolimus ointment (Protopic®).

The Journal of dermatological treatment·2017
Same author

Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5).

Clinical and translational allergy·2017
Same author

Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5).

Clinical and translational allergy·2016
Same author

MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation.

Allergy·2015
Same author

Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs.

The Journal of allergy and clinical immunology·2012

Area of Science:

  • Dermatology
  • Pharmacology
  • Clinical Toxicology

Background:

  • Topical antifungal agents, particularly imidazole derivatives, are widely used.
  • Allergic contact dermatitis is a potential adverse reaction to topical medications.
  • Tioconazole is a commonly prescribed imidazole antifungal agent.

Purpose of the Study:

  • To investigate the incidence of allergic patch test reactions to tioconazole.
  • To explore potential cross-reactivity between tioconazole and other imidazole derivatives.
  • To identify factors contributing to an apparent increase in tioconazole allergies.

Main Methods:

  • Retrospective analysis of allergic patch test results over a 15-month period.
  • Identification of patients with positive patch test reactions to tioconazole.
  • Assessment of patient history regarding sensitization to other imidazole antifungals.

Main Results:

  • 14 patients exhibited allergic patch test reactions to tioconazole.
  • 9 out of 14 patients (64%) also showed allergies to other imidazole derivatives.
  • A strong possibility of cross-reactivity between structurally similar imidazole antifungals was identified.

Conclusions:

  • Tioconazole can cause allergic contact dermatitis, potentially due to cross-reactivity with other imidazoles.
  • Widespread use of concentrated tioconazole formulations may contribute to increased allergic reactions.
  • Further investigation into cross-reactivity patterns among imidazole antifungals is warranted.

Related Experiment Videos