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[Disorders of gastric emptying]
1Service d'Hépato-Gastroentérologie, Hôpital Saint-Louis, Paris.
Presse Medicale (Paris, France : 1983)
|June 20, 1992
Summary
Gastric emptying disorders present diverse symptoms and complex mechanisms, often linked to diabetes, functional gastrointestinal disorders, or surgery. Current treatments focus on diet and medications like metoclopramide, with new therapies under development.
Area of Science:
- Gastroenterology
- Physiology
Context:
- Disorders of gastric emptying are common in various clinical settings.
- Symptoms are often non-specific and poorly correlated with objective emptying abnormalities.
- Key mechanisms involve disruptions in electrical rhythm, fundic compliance, antral motility, and antro-pyloro-duodenal coordination.
Purpose:
- To review the pathophysiology and clinical presentation of gastric emptying disorders.
- To identify predominant etiological factors and their associated mechanisms.
- To outline current and emerging therapeutic strategies for gastric stasis.
Summary:
- Gastric emptying disorders stem from complex physiological dysfunctions, notably affecting motility and coordination.
- Diabetes mellitus, functional gastrointestinal disorders (idiopathic dyspepsia), and post-surgical states are primary causes.
- These conditions can manifest with paradoxical solid retention and liquid hyper-evacuation.
Impact:
- Highlights the disconnect between symptoms and objective findings in gastric emptying disorders.
- Emphasizes the multifactorial nature of these conditions, requiring tailored treatment approaches.
- Informs clinical practice regarding dietary management and pharmacological interventions, including novel motilin agonists.