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NK cells and T cells: mirror images?
1Dept of Human Genetics, University of Amsterdam, The Netherlands.
Immunology Today
|July 1, 1992
Abstract:
The expression of MHC class I molecules protects cells against lysis by natural killer (NK) cells. It is possible that NK cells are 'educated' to recognize self MHC class I molecules and that the combination of self peptide and MHC class I molecule blocks NK-mediated lysis. Here, Rogier Versteeg compares and contrasts models of education and self-nonself discrimination by T cells and NK cells, and presents a hypothesis for the evolution of T cells from NK cells.