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Long-term clinical experience with a topical retinoid.
1R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869-0602.
The British Journal of Dermatology
|September 1, 1992
Summary
Topical tretinoin effectively treats acne and photodamaged skin with minimal side effects. Continued use, even intermittently, maintains improvements in skin texture and reduces signs of sun damage.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Topical tretinoin is a recognized acne treatment with a favorable safety profile, primarily causing local skin reactions.
- Limited systemic absorption of tretinoin ensures plasma concentrations remain within normal endogenous levels.
Purpose of the Study:
- To evaluate the efficacy of topical tretinoin in treating acne and signs of photodamage.
- To assess the long-term maintenance of therapeutic effects and potential role in solar keratosis treatment.
Main Methods:
- Review of adverse effects and plasma concentrations from clinical trials.
- Assessment of skin texture and tumorigenic effects in mice.
- Multicentre clinical trials evaluating tretinoin emollient cream for photodamage and solar keratoses.
Main Results:
- Tretinoin demonstrated low incidence of adverse effects, mainly local skin reactions.
- Lifetime topical application in mice showed improved skin texture without tumorigenic effects.
- 0.05% tretinoin emollient cream reduced wrinkles, roughness, and hyperpigmentation from photodamage, with effects maintained by intermittent therapy.
- 0.1% tretinoin cream showed potential in treating solar keratoses.
Conclusions:
- Topical tretinoin is safe and effective for acne.
- Intermittent application of tretinoin maintains improvements in photodamaged skin.
- Tretinoin, combined with sun protection, is an effective strategy for managing chronic sun damage.