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Spectrophotometric determination of promethazine by flow injection analysis and oxidation by CeIV
J Martinez Calatayud1, T Garcia Sancho
1Departamento de Quimica Analitica, Universidad de Valencia, Spain.
Journal of Pharmaceutical and Biomedical Analysis
|January 1, 1992
Abstract:
A flow injection analysis (FIA) procedure is proposed for the determination of promethazine. The sample solution is directly injected into the carrier-reagent stream which comprises a solution of ceric ions in a sulphuric acid medium. The absorbance at 514 nm from the red colour developed by the oxidation of promethazine is measured. Effects of foreign substances have been investigated and the procedure has been applied to the determination of promethazine in a pharmaceutical formulation (tablets).