Related Experiment Video
Updated: Sep 21, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
Published on: June 23, 2023
Acute-On-Chronic Liver Failure With Discordant Severity Assessments Following Binge Drinking: A Case Report
Minami Seki1, Tomoyuki Watanabe2, Yuma Haraguchi3
1Division of Internal Medicine Health Co-op. Watari Hospital Fukushima Japan.
Abstract:
Acute-on-chronic liver failure (ACLF) is associated with high short-term mortality. We report a man in his 50s with alcohol-related cirrhosis who developed ACLF following binge drinking. Despite being classified as grade 1 ACLF according to the Japanese severity classification, he presented with severe metabolic acidosis and marked hyperlactatemia and died 4 h after admission. Another prognostic scoring system classified him in the most severe category. This case illustrates that different severity assessments may provide complementary information regarding ACLF severity and prognosis and underscores the importance of repeatedly addressing problematic alcohol use and facilitating engagement in specialized addiction treatment during outpatient care.
Related Concept Videos
Cirrhosis II: Pathophysiology
Cirrhosis I: Introduction
Hepatic Encephalopathy
Diseases of the Liver and Gallbladder
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Esophageal Varices-II: Clinical Features and Management
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
Chronic Pancreatitis II: Pathophysiology
