[Lysosomes, cellular digestion and immune processes]

The article presents a survey of the available literature concerned with the problems of relationships between the functions of the lysosomal apparatus of cells of the reticuloendothelial system and immune processes. A connection between the primary lysosoma and endocytic vacuole, desintegration of absorbed antigens by micro- and macrophages, the significance of antigenic information transmitted by macrophage to an immune lymphocyte, and realization of the immune response are traced carefully and in succession. Participation of lysosomas in antigen-antibody reactions (anaphylaxis, Arthus' phenomenon, supersensitivity of a delayed type) and their role in induction of immune tolerance and in some autoimmune processes are also considered.